性别

男

出生年月

1976.12

职称

教授

学历（学位）

博士

所属院系

Betway必威西蒙体育

导师类别

博士生导师

行政职务

副董事长

招生专业

分析化学，应用化学

研究方向

生化分析，光电传感，可穿戴传感器

联系方式

13505422716，xiliangluo@qust.edu.cn

个人简历（包括近期科研项目）

罗细亮，男，1976年12月出生，山东省二级教授，国家优秀青年基金获得者，山东省泰山学者特聘教授，博士生导师。先后在必威BETWAY官网获得学士和硕士学位，2005年于南京大学获得分析化学博士学位，导师为陈洪渊院士。2005年到2011年先后在爱尔兰都柏林城市大学、美国亚利桑那州立大学和匹兹堡大学从事博士后研究。2011年2月依托英国牛津大学化学系获批为欧盟玛丽居里学者；3月被美国匹兹堡大学聘为研究助理教授；2011年9月被山东省政府选聘为生化分析岗位泰山学者特聘教授（2016年泰山学者聘期考核优秀，获得连续资助）。2014年初任Betway必威西蒙体育副经理，及光电传感与生命分析教育部重点实验室副主任；2016年底任经理、重点实验室主任；2022年中起任必威BETWAY官网副董事长。

作为山东省高校黄大年式教师团队负责人，长期从事生命分析化学及电化学相关教学与科研工作。在光电传感及成像分析领域开展了有特色的研究工作，提出并发展了抗污染生物传感器的概念，在国内外产生了积极影响。在Chemical Reviews、Analytical Chemistry等期刊发表论文260余篇，被引用12000余次；授权国家发明专利10余项。2011年以来主持国家优秀青年科学基金1项，国家自然科学基金面上项目5项，山东省杰出青年基金1项，青岛市重点项目1项。作为负责人获批国家级虚拟仿真实验教学项目1项，国家级一流课程1门。指导本科生获国家级大创项目7项，指导研究生获山东省优博5篇；以第一完成人获得中国分析测试协会科学技术奖一等奖1项，山东省自然科学奖二等奖1项。先后获评必威BETWAY官网优秀共产党员，青岛市劳动模范，山东省优秀研究生指导教师。目前为山东省科协常委，并应邀担任国际SCI期刊《Microchimica Acta》副主编、《Diamond and Related Materials》编辑，以及中文核心期刊《分析测试学报》编委。

工作经历

2011.09 -至今必威BETWAY官网，Betway必威西蒙体育，泰山学者特聘教授

2011.11 - 2013.10 英国牛津大学，化学系，高级玛丽居里学者

2011.03 - 2011.09 美国匹兹堡大学，生物工程系，研究助理教授

2008.06 - 2011.02 美国匹兹堡大学，生物工程系，博士后研究员

2007.03 - 2008.05 美国亚利桑那州立大学，生物设计研究院，博士后研究员

2005.05 - 2007.03 爱尔兰都柏林城市大学，国家传感器研究中心，博士后

主持科研项目

1）国家自然科学基金面上项目（2024.01-2027.12），抗污染表皮电化学传感器的构建及其在皮肤间质液检测中的应用，22374085，50万；

2）国家自然科学基金面上项目（2022.01-2025.12），抗污染柔性电化学传感器的构建及其在汗液检测中的应用，22174082，60万；

3）青岛市科技惠民示范引导专项重点项目（2020.06-2023.06），可穿戴智能医疗监测设备的研制及在康复医学中的应用，20-3-4-53-nsh，100万；

4）国家自然科学基金面上项目（2020.01-2023.12），超薄二维材料增强的柔性导电聚合物制备及其在可穿戴传感器中的应用，21974075，66万；

5）泰山学者建设工程专项（2017.01-2021.12），生化分析，ts20110829连续资助，200万；

6）国家自然科学基金面上项目（2017.01-2020.12），多肽功能化抗污染疾病标志物传感器的研制及其在复杂生物样品中的检测应用，21675093，65万；

7）山东省杰出青年基金（2014.12-2017.12），生化分析及生物传感，JQ201406，60万；

8）国家优秀青年科学基金（2015.01-2017.12），生化分析，21422504，100万；

9）国家自然科学基金面上项目（2013.01-2016.12），单根导电聚合物纳米线的可控原位合成及其在癌症标志物检测中的应用，21275087，80万；

10）山东省自然科学基金面上项目（2012.07-2015.07），基于单根导电聚合物纳米线的疾病标志物超灵敏生物传感器，ZR2012BM008，10万；

11）泰山学者建设工程专项（2011.09-2016.09）， 生化分析，ts20110829，200万；

12）欧盟第七框架计划研究项目（2011.11-2013.10），Multiplexed protein and kinase activity detection assays in complex media using impedance/capacitance，271775，28万欧元。

代表性论文

1）Nianzu Liu, Ruoxing Wang, Shengjie Gao, Ruifang Zhang, Fengru Fan, Yihui Ma,Xiliang Luo^*, Dong Ding^*, Wenzhuo Wu^*.High-performance piezo-electrocatalytic sensing of ascorbic acid with nanostructured wurtzite zinc oxide.Advanced Materials, 231 (2021) 2105697.

2）Shuwei Chen, Yue Yin, Xiaozhe Pang, Congkai Wang, Lei Wang, Junqi Wang, Jiangfei Jia, Xinxue Liu, Shenghao Xu^*,Xiliang Luo^*.Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution.Chemical Science, 15 (2024) 566-572.

3）Chen-chen Li, Hui-yan Chen,Xiliang Luo^*, Juan Hu^*, Chun-yang Zhang^*. Multicolor fluorescence encoding of different microRNAs in lung cancer tissues at the single-molecule level.Chemical Science, 12 (2021) 12407-12418.

4）Wenjuan Song, Zhi-Ling Song^*, Qian Li, Chengwen Shang, Qiqi Chao, Xingfu Liu, Rongmei Kong, Gao-Chao Fan,Xiliang Luo^*.A cell-anchored and self-calibrated DNA nanoplatform forin situimaging and quantification of endogenous miRNA in live cells: introducing two controls to normalize the sensing signals.CCS Chemistry,5(2023) 176-190.

5）Yang Li, Rui Han, Jiahui Feng, Jialu Li,Xiliang Luo^*.Phospholipid bilayer integrated with multifunctional peptide for ultralow-fouling electrochemical detection of HER2 in human serum.Analytical Chemistry, 96 (2024) 531-537.

6）Rui Han, Yang Li, Mingjun Shi, Caifeng Ding,Xiliang Luo^*.Designed polyhydroxyproline helical peptide with ultrarobust antifouling capability for electrochemical sensing in diverse complex biological fluids.Analytical Chemistry, 95 (2023) 18540-18548.

7）Xiujuan Qiao, Zeng-Hui Qian, Wenpeng Sun, Chuan-Yong Zhu, Yanxin Li,Xiliang Luo^*. Phosphorylation of oligopeptides: Design of ultra-hydrophilic zwitterionic peptides for anti-fouling detection of nucleic acids in saliva.Analytical Chemistry, 95 (2023) 11091-11098.

8）Rui Han, Yang Li, Wenjie Hou, Caifeng Ding^*,Xiliang Luo^*.Designed multifunctional isopeptide for enhanced Annexin A1 biosensing based on peptide–protein interactions in human blood.Analytical Chemistry, 95 (2023) 9025-9033.

9）Rui Han, Yang Li, Min Chen, Wanting Li, Caifeng Ding,Xiliang Luo^*.Antifouling electrochemical biosensor based on the designed functional peptide and the electrodeposited conducting polymer for CTC analysis in human blood.Analytical Chemistry, 94 (2022) 2204-2211.

10）Yang Li, Rui Han, Min Chen, Xiqin Yang, Yinan Zhan, Lei Wang,Xiliang Luo^*.Electrochemical biosensor with enhanced antifouling capability based on amyloid-like bovine serum albumin and a conducting polymer for ultrasensitive detection of proteins in human serum.Analytical Chemistry, 93 (2021) 14351-14357.

11）Min Chen, Rui Han, Wenqi Wang, Yang Li,Xiliang Luo^*. An antifouling aptasensor based on self-assembled loop-closed peptides with enhanced stability for CA125 assay in complex biofluids.Analytical Chemistry, 93 (2021) 13555-13563.

12）Wenqi Wang, Rui Han, Min Chen,Xiliang Luo^*.Antifouling peptide hydrogel based electrochemical biosensors for highly sensitive detection of cancer biomarker HER2 in human serum.Analytical Chemistry, 93 (2021) 7355-7361.

13）Zhen Song, Yihui Ma, Min Chen, Adriano Ambrosi, Caifeng Ding^*,Xiliang Luo^*.Electrochemical biosensor with enhanced antifouling capability for COVID-19 nucleic acid detection in complex biological media.Analytical Chemistry, 93 (2021) 5963-5971.

14）Yang Li, Rui Han, Min Chen, Leyao Zhang, Guixiang Wang^*,Xiliang Luo^*.Bovine serum albumin-cross-linked polyaniline nanowires for ultralow fouling and highly sensitive electrochemical protein quantification in human serum samples.Analytical Chemistry, 93 (2021) 4326-4333.

15）Shiting Gu, Xiao-Mei Shi, Di Zhang, Gao-Chao Fan^*,Xiliang Luo^*.Peptide-based photocathodic biosensors: integrating a recognition peptide with an antifouling peptide.Analytical Chemistry, 93 (2021) 2706-2712.

16）Guixiang Wang, Rui Han, Qun Li, Yinfeng Han,Xiliang Luo^*.Electrochemical biosensors capable of detecting biomarkers in human serum with unique long-term antifouling abilities based on designed multifunctional peptides.Analytical Chemistry, 92 (2020) 7186-7193.

17）Zhen Song, Min Chen, Caifeng Ding,Xiliang Luo^*.Designed three-in-one peptides with anchoring, antifouling and recognizing capabilities for highly sensitive and low fouling electrochemical sensing in complex biological media.Analytical Chemistry, 92 (2020) 5795-5802.

18）Nianzu Liu, Jingyao Song, Yanwei Lu, Jason J. Davis, Fengxian Gao,Xiliang Luo^*. Electrochemical aptasensor for ultralow fouling cancer cell quantification in complex biological media based on designed branched peptides.Analytical Chemistry, 91 (2019) 8334-8340.

19）Shenghao Xu, Yongyin Nie, Liping Jiang, Jun Wang, Guiyun Xu, Wei Wang,Xiliang Luo^*.Polydopamine nanosphere/gold nanocluster (Au NC)-based nanoplatform for dual color simultaneous detection of multiple tumor-related microRNAs with DNase-I-assisted target recycling amplification.Analytical Chemistry, 90 (2018) 4039-4045.

20）Xiujuan Qiao, Yuchen Cai, Zhaoyang Kong, Zhenying Xu,Xiliang Luo^*. A wearable electrochemical sensor based on anti-fouling and self-healing polypeptide complex hydrogels for sweat monitoring.ACS Sensors, 8 (2023) 2834-2842.

21）Shuju Zhao, Xiujuan Qiao, Min Chen, Yanxin Li, Xin Wang, Zhenying Xu, Yumin Wu^*,Xiliang Luo^*.D-amino acid-based antifouling peptides for the construction of electrochemical biosensors capable of assaying proteins in serum with enhanced stability.ACS Sensors, 7 (2022) 1740-1746.

22）Nianzu Liu, Ni Hui, Jason J. Davis,Xiliang Luo^*.Low Fouling Protein Detection in Complex Biological Media Supported by a Designed Multifunctional Peptide.ACS Sensors, 3 (2018) 1210-1216.

23）Min Cui, Yu Wang,Mingxia Jiao,Silambarasan Jayachandran, Yumin Wu,Xiaojian Fan,Xiliang Luo^*.Mixed self-assembled aptamer and newly designed zwitterionic peptide as antifouling biosensing interface for electrochemical detection of alpha-fetoprotein.ACSSensors,2 (2017) 490-494.

综述论文

1）Cheng Jiang, Guixiang Wang, Robert Hein, Nianzu Liu,Xiliang Luo^*, Jason J. Davis^*. Antifouling strategies for selective in vitro and in vivo sensing.Chemical Reviews, 120 (2020) 3852-3889.

2）Xiliang Luo, Jason J. Davis*. Electrical biosensors and the label free detection of protein disease biomarkers.Chemical Society Reviews,42 (2013) 5944-5962.

3）Zhen Song, Yihui Ma, Aoife Morrin, Caifeng Ding^*,Xiliang Luo^*.Preparation and electrochemical sensing application of porous conducting polymers.TrAC-Trends in Analytical Chemistry, 135 (2021) 116155.

4）Min Cui^*, Yihui Ma, Lei Wang, Yu Wang, Shuai Wang,Xiliang Luo^*. Antifouling sensors based on peptides for biomarker detection.TrAC-Trends in Analytical Chemistry, 127 (2020) 115903.

5）Guixiang Wang, Aoife Morrin, Mengru Li, Nianzu Liu,Xiliang Luo^*. Nanomaterial-doped conducting polymers for electrochemical sensors and biosensors.Journal of Materials Chemistry B,6 (2018) 4173-4190.

6）Xiliang Luo, Aoife Morrin, Anthony J. Killard, Malcolm R. Smyth^*. Application of nanoparticles in electrochemical sensors and biosensors.Electroanalysis,18 (2006) 319-326.引用1079次。